Zofran® has been linked to numerous side effects including: spina bifida, heart defects, cleft palet, PPHN, Autism/ADHD/Behavior Problems, Club Foot, Internal Malformation and lung defects. Reports indicated that up to 20% of babies born to women taking Zofran during their pregnancy saw some form of birth defect upon delivery. The risk of birth defect is 30% higher for babies born to mothers who took Zofran in the first trimester.
The major defect exhibiting in babies have been various types of heart problems. Zofran has doubled the risk of Atrial and Ventricular Septal Defects (also may be know as "hole in the heart"). ASD and VSD are holes in the upper and lower chambers of the heart which can cause major circulation issues in the baby.